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R©ussir le DELF B1. Learning French in France.R©ussir le DELF B1. The first DELF test for adults. Download and read the free DELF B1 book in English.R©ussir le DELF B1. This document was published by user on sep 21, 2014. free download here. Free DELF B1 training book. [formato PDF].R©ussir le DELF B1. This is the publication number of the complete book Delf B1 in English (pdf.delf a2 practice and mock examsDelf B1 pdf book R©ussir le. R©ussir le DELF B1 by la chaleur jeune. The DELF B1 will test you on the four language skills: reading, writing, listening, and speaking.R©ussir le DELF B1. This document was published by user and they confirmed that they have the permission to distribute this document.Global regulators of alternative splicing of the pro-apoptotic protein PUMA.Puma (also known as BNIP3) is a pro-apoptotic protein of the BCL-2 protein family encoded by the BH3-only gene BNIP3. Puma is a BH3-only protein able to interact with prosurvival proteins as BCL-2 or BCL-XL and to induce cytochrome c release and apoptosis. We and others have observed that the mRNA of Puma contains seven exons (exons 1-7). However, the nature of the transcripts that can potentially result from these exons remains unclear. We performed a series of experiments to identify factors that regulate alternative splicing of the Puma pre-mRNA and found that some of these proteins were localized in the nucleus and could associate with Puma pre-mRNA. We assessed the effect of overexpression of these proteins on Puma alternative splicing. In addition, we identified a sequence enriched in the Puma-5' UTR that was recognized by a cellular protein that enhanced splicing and we identified a RNA-binding protein, hnRNP H, that repressed exon 6 inclusion by binding to this sequence and inhibiting the interaction of the splicing factors SF1 and U2AF65 with the pre-mRNA.
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