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Vitamin D3 has been found to inhibit proliferation of human gastric cancer cells in vitro. The mechanism by which vitamin D3 exerts an anticancer effect is not well understood. In this study, immunohistochemical staining of the vitamin D3 receptor (VDR) was performed in a cohort of 41 gastric cancers. VDR-positive cells were found in both tumor cells and stroma. VDR was present in the nuclei of gastric tumor cells and in tumor-associated stromal cells. In comparison with staining in normal gastric mucosa, VDR expression was decreased in primary tumors of stage III-IV. Gastric tumor cells which express the VDR are more likely to show a good response to antitumor effects of vitamin D3.The new television season is upon us, and with it comes more bad Apple TV+ content. Amazon Prime Video has posted the first trailer for the second season of the sci-fi anthology series, and it features tons of great science fiction and fantasy-inspired clips that promise to be even better than Season One. “You will be connected with something you’ve never seen before in your life,” said Amazon Prime Video head of original content Jennifer Salke in an interview with Variety. “ 0b46394aab